Researchers Have Advanced CTE Tests for Living Patients
Scientists are developing imaging and blood tests to identify chronic traumatic encephalopathy in the brain.
Updated on Sept. 22, 2026 in Alzheimer’s
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New diagnostic methods for chronic traumatic encephalopathy (CTE) are currently in development, aiming to move beyond the current requirement of post-mortem analysis. These advancements seek to identify the condition in living patients, potentially aiding families in preparing for behavioral changes.
Why it matters
A definitive diagnosis in living patients remains a major hurdle, as current methods rely on processes of elimination. Early identification would allow scientists to better track the progression of the condition and develop future clinical treatments.
Researchers at Boston University have analyzed tissue from the UNITE Brain Bank, which stores over 1,800 brains, 50% of which were diagnosed with CTE. Ongoing efforts include a Phase 3 trial testing a PET scan biomarker and blood sampling to match findings to post-mortem evidence.
The players
UNITE Brain Bank
A research facility at Boston University that maintains a repository of donated brains to advance the study of neurodegenerative diseases.
Dr. Vasdev
A researcher leading radiochemistry efforts to visualize tau proteins in the brain for the detection of neurodegenerative conditions.
The details
CTE is characterized by the accumulation of tau proteins that change shape and form clusters following repeated head trauma. Researchers are now developing radiochemistry tracers, such as OXD-2314, to bind to these specific tau proteins, making them visible on PET scans. Additionally, scientists are exploring blood tests to detect markers of neuron damage and inflammation associated with the condition.
Timeline
2012: Ralph Wenzel passed away at age 69.
August 2026: A study on CTE prevalence in NFL players was published.
Health Landscape
Current diagnostic standards for CTE rely on the UNITE Brain Bank's collection to confirm cases after death. Moving these diagnostics to living patients marks a significant shift from reactive autopsy-based science to proactive clinical detection.
While these diagnostic tools are currently in development, they underscore the importance of monitoring neurological symptoms following repeated head impacts. Discuss any concerns regarding cognitive or behavioral changes with a neurologist to explore the most current clinical evaluation options.
The takeaway
Diagnosing CTE during life is an active, ongoing field of study that aims to change how we understand brain health. Keep informed on clinical trial updates and consult your physician if you have specific concerns about head trauma and long-term cognitive health.
Further reading
Learn more about the latest innovations in neurodegenerative diagnostics in our Alzheimer’s section.
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