New Migraine Treatment Guidelines Have Been Published
The American Academy of Neurology updated its approach to migraine management for patients having four or more monthly episodes.
Updated on Sept. 24, 2026 in Stroke
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The American Academy of Neurology released its first updated migraine treatment guidelines since 2012. The new recommendations emphasize preventive care for patients who experience four or more migraines per month.
Why it matters
This update reflects significant changes in how neurologists manage migraines, moving toward a framework that treats migraine as a chronic neurological disease rather than an occasional symptom. The guidelines aim to improve patient outcomes by standardizing the use of modern preventive therapies.
The updated guidelines replace the 2012 standards and incorporate advancements in migraine care developed over the last 14 years. These recommendations are based on a review of therapeutic efficacy for millions of people worldwide living with the condition.
The players
American Academy of Neurology
A professional medical association of neurologists and neuroscientists dedicated to promoting the highest quality of patient-centered neurological care.
The details
The new guidance supports the use of CGRP inhibitor medications as a first-line preventive therapy to block proteins involved in pain signaling. For patients utilizing Botox, the guidelines instruct physicians to assess treatment efficacy after 24 weeks, or two rounds, to determine if the intervention is providing measurable relief. The framework also prioritizes a collaborative, shared decision-making process between patients and their physicians to tailor treatment plans to individual health needs.
Timeline
2012: The American Academy of Neurology published previous migraine treatment guidelines.
September 2026: The American Academy of Neurology published the updated guidelines.
Health Landscape
This update follows the 2012 American Academy of Neurology migraine guidelines and marks a significant evolution in standard care. It reflects the broader transition toward managing migraine as a chronic neurological disease through newer, targeted preventive therapies.
If you experience four or more migraine days per month, it is worth discussing these new treatment options with your doctor. You should specifically ask your physician whether current preventive therapies or Botox could be appropriate for your condition.
The takeaway
Migraine management is shifting toward a more proactive, disease-based preventive model. Consider tracking your monthly migraine frequency to help your doctor determine if you meet the threshold for starting or adjusting preventive care.
Further reading
Learn more about managing neurological conditions in our Stroke section.
Source note: This article includes information reported by Prevention.
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